Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7406 |
AKR1C3-IN-1
3-(3,4-二氢-1H-异喹啉-2-磺酰基)-苯甲酸 |
NADPH | Metabolism |
AKR1C3-IN-1 是高度选择性的 AKR1C3抑制剂(IC50:13 nM)。 | |||
T61790 | AKR1C3-IN-6 | ||
AKR1C3-IN-6 (Compound 1) is a powerful and specific inhibitor of AKR1C3, with IC50 values of 0.31 μM and 73.23 μM against AKR1C3 and AKR1C2, respectively. It demonstrates significant antitumor activity [1]. | |||
T79433 |
AKR1C3-IN-10
|
||
AKR1C3-IN-10 (化合物 5r),作为一种具有选择性的AKR1C3抑制剂 (IC50=51 nM),在前列腺癌异种移植模型中表现出了良好的生物活性。 | |||
T78199 |
S07-1066
|
Others | Others |
S07-1066为AKR1C3醛酮还原酶抑制剂,增强阿霉素(DOX)细胞毒性作用。该化合物选择性抑制AKR1C3催化的DOX还原反应,逆转AKR1C3高表达细胞的DOX耐药性。 | |||
T61511 |
S07-2005 (racemic)
|
||
S07-2005 racemic is a chemically potent and selective inhibitor of aldo-keto reductase 1C3 (AKR1C3), with an IC50 value of 0.13 μM and 0.75 μM for AKR1C3 and AKR1C4, respectively. Due to its inhibitory properties, it exhibits potential as a chemotherapeutic potentiator, specifically in the context of overcoming drug resistance in cancer [1]. | |||
T61485 | S07-2010 | ||
S07-2010 is a potent pan-AKR1C inhibitor, effectively inhibiting AKR1C3, AKR1C4, AKR1C1, and AKR1C2 with IC50 values of 0.19, 0.36, 0.47, and 0.73 μM, respectively. This compound induces apoptosis in A549/DDP cells and enhances the cytotoxicity of chemotherapeutic agents in drug-resistant cells, making it a viable option for combating drug resistance. Furthermore, S07-2010 significantly inhibits the proliferation of drug-resistant cells [1]. |